NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
نویسندگان
چکیده
منابع مشابه
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation.
Metabolic reprogramming is implicated in macrophage activation, but the underlying mechanisms are poorly understood. Here, we demonstrate that the NOTCH1 pathway dictates activation of M1 phenotypes in isolated mouse hepatic macrophages (HMacs) and in a murine macrophage cell line by coupling transcriptional upregulation of M1 genes with metabolic upregulation of mitochondrial oxidative phospho...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci76468